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John Ryu is a third-year student majoring in microbiology. His research focuses on cancer immunology, specifically studying the anti-tumor effects of a relatively new class of cancer drugs.
What specifically do you research? What projects are you currently working on?
I work in a hematology-oncology translational research lab with the Ohio State University Comprehensive Cancer Center. My current independent research project examines the effects of a novel anti-cancer drug on healthy immune system function. Understanding if and how cancer drugs affect the immune system is important, since a damaged or inhibited immune system can negatively affect patient survival and quality of life. Previous research projects I have contributed to include the use of therapeutic monoclonal antibodies and apoptotic receptor modulation against hematological malignancies in vitro and in vivo.
How did you find this research topic?
I started looking for a basic science research laboratory my freshman year and thought “Cancer Research” seemed like an interesting enough topic to look into. I eventually found a lab I liked and that was willing to take me on as a volunteer. Initially, I worked as a research assistant to several other researchers in the lab. After several months, the primary investigator (PI) gave me an independent project to work on. I’ve spent the last two years examining T and NK cell functionality in the presence of various histone deacetylase inhibitors, and it’s been absolutely incredible to see how the project evolves over time as new questions and new theories enter the investigation.
What are the benefits of participating in research?
I've learned lessons that I will carry with me for the rest of my life. I’ve learned how to work independently, through setting up my own experiments and guiding the direction of my project. I’ve also worked with all sorts of different people, from lab assistants and undergraduates to postdocs and primary investigators. I’ve learned from their experiences and formed meaningful connections. Research has also taught me how to work through failure and instilled in me the spirit of perseverance. Instead of giving up, I’ve trained myself to always approach a problem in a new way by constantly asking questions. These lessons can’t be taught in the classroom and will help you succeed regardless of your field of study.
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